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The complex etiology of autism spectrum disorder due to missense mutations of CHD8.
Mol. Psychiatry, 29: 2145-2160, 2024. -
Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression.
Nucleic Acids Res., 52: 2995-3010, 2024. -
Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis.
PLoS One, 18: e0288930, 2023. -
Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons.
Commun. Biol., 6: 593, 2023. -
A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.
Nature Methods, 19: 1286-1294, 2022. -
Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.
BMC Neurosci., 22: 32, 2021. -
The autism-associated protein CHD8 is required for cerebellar development and motor function.
Cell Rep., 35: 108932, 2021. -
The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells.
Cell Rep., 34: 108688, 2021. -
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
Mol. Brain, 13: 160, 2020. -
Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
Genes Cells, 25: 427-38, 2020. -
Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.
Hum. Mol. Genet., 29: 1274-91, 2020. -
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
J. Exp. Med., 216: 950-65, 2019. -
The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
Cell Rep., 23: 1988-2000, 2018. -
Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
Nature Commun., 8: 16114, 2017. -
FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
Mol. Cell. Biol., 37: e00470-16, 2017. -
CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
Nature, 537: 675-9, 2016. -
FBXL12 regulates T cell differentiation in a cell-autonomous manner.
Genes Cells, 5: 517-24, 2016. -
FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development.
Stem Cells, 33: 3327-40, 2015. -
MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-box RNA helicase DDX24.
Mol. Cell. Biol., 34: 3321-40, 2014. -
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
J. Biol. Chem., 289: 16430-41, 2014. -
Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway.
Mol. Cell. Biol., 32: 501-12, 2012. -
Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L.
Genes Cells, 17: 536-47, 2012. -
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Cell Metab., 14: 339-51, 2011. -
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
Nature Cell Biol., 11: 172-82, 2009. -
Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
Mol. Cell. Biol., 26: 6157-69, 2006. -
Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.
Cancer Sci., 97: 729-36, 2006. -
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
EMBO J., 23: 2116-25, 2004. -
Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.
Mol. Cell. Biol., 24: 8386-94, 2004. -
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
J. Biol. Chem., 279: 9417-23, 2004.
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