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論文

  1. Shiraishi T., Katayama Y., Nishiyama M., Shoji H., Miyakawa T., Mizoo T., Matsumoto A., Hijikata A., Shirai T., Mayanagi K., Nakayama KI.
    The complex etiology of autism spectrum disorder due to missense mutations of CHD8.
    Mol. Psychiatry, 29: 2145-2160, 2024.
  2. Nitahara K., Kawamura A., Kitamura Y., Kato K., Namekawa SH., Nishiyama M.
    Chromatin remodeler CHD8 is required for spermatogonial proliferation and early meiotic progression.
    Nucleic Acids Res., 52: 2995-3010, 2024.
  3. Takana Y., Nakata T., Hibino H., Nishiyama M., Ino D.
    Classification of multiple emotional states from facial expressions in head-fixed mice using a deep learning-based image analysis.
    PLoS One, 18: e0288930, 2023.
  4. Kawamura A., Nishiyama M.
    Deletion of the autism-related gene Chd8 alters activity-dependent transcriptional responses in mouse postmitotic neurons.
    Commun. Biol., 6: 593, 2023.
  5. Ino D., Tanaka Y., Hibino H., Nishiyama M.
    A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain.
    Nature Methods, 19: 1286-1294, 2022.
  6. Cherepanov SM., Gerasimenko M., Yuhi T., Furuhara K., Tsuji C., Yokoyama S., Nakayama KI., Nishiyama M., Higashida H.
    Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.
    BMC Neurosci., 22: 32, 2021.
  7. Kawamura A., Katayama Y., Kakegawa W., Ino D., Nishiyama M., Yuzaki M., Nakayama KI.
    The autism-associated protein CHD8 is required for cerebellar development and motor function.
    Cell Rep., 35: 108932, 2021.
  8. Nita A., Muto Y., Katayama Y., Matsumoto A., *Nishiyama M., *Nakayama KI. (*Corresponding authors)
    The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells.
    Cell Rep., 34: 108688, 2021.
  9. Kawamura A., Abe Y., Seki F., Katayama Y., Nishiyama M., Takata N., Tanaka KF., Okano H., Nakayama KI.
    Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain.
    Mol. Brain, 13: 160, 2020.
  10. Yamauchi Y., Nita A., Nishiyama M., Muto Y., Shimizu H., Nakatsumi H., Nakayama KI.
    Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development.
    Genes Cells, 25: 427-38, 2020.
  11. Kawamura A., Katayama Y., *Nishiyama M., Shoji H., Tokuoka K., Ueta Y., Miyata M., Isa T., Miyakawa T., Hayashi-Takagi A., *Nakayama KI. (*Corresponding authors)
    Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice.
    Hum. Mol. Genet., 29: 1274-91, 2020.
  12. Muto Y., Moroishi T., Ichihara K., *Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., *Nakayama KI. (*Corresponding authors)
    Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
    J. Exp. Med., 216: 950-65, 2019.
  13. Kita Y., Katayama Y., Shiraishi T., Oka T., Sato T., Suyama M., Ohkawa Y., Miyata K., Oike Y., Shirane M., *Nishiyama M., *Nakayama KI. (*Corresponding authors)
    The autism-related protein CHD8 cooperates with C/EBPβ to regulate adipogenesis.
    Cell Rep., 23: 1988-2000, 2018.
  14. Muto Y., *Nishiyama M., Nita A., Moroishi T., *Nakayama KI. (*Corresponding authors)
    Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.
    Nature Commun., 8: 16114, 2017.
  15. Yamauchi T., *Nishiyama M., Moroishi T., Kawamura A., *Nakayama KI. (*Corresponding authors)
    FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem-progenitor cells.
    Mol. Cell. Biol., 37: e00470-16, 2017.
  16. Katayama Y., *Nishiyama M., Shoji H., Ohkawa Y., Kawamura A., Sato T., Suyama M., Takumi T., Miyakawa T., *Nakayama KI. (*Corresponding authors)
    CHD8 haploinsufficiency results in autistic-like phenotypes in mice.
    Nature, 537: 675-9, 2016.
  17. Nita A., *Nishiyama M., Muto Y., *Nakayama KI. (*Corresponding authors)
    FBXL12 regulates T cell differentiation in a cell-autonomous manner.
    Genes Cells, 5: 517-24, 2016.
  18. Nishiyama M., Nita A., Yumimoto K., Nakayama KI.
    FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development.
    Stem Cells, 33: 3327-40, 2015.
  19. Yamauchi T., Nishiyama M., Moroishi T., Yumimoto K., Nakayama KI.
    MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-box RNA helicase DDX24.
    Mol. Cell. Biol., 34: 3321-40, 2014.
  20. Moroishi T., Yamauchi T., Nishiyama M., Nakayama KI.
    HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
    J. Biol. Chem., 289: 16430-41, 2014.
  21. Nishiyama M., Skoultchi AI., Nakayama KI.
    Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway.
    Mol. Cell. Biol., 32: 501-12, 2012.
  22. Kita Y., Nishiyama M., Nakayama KI.
    Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L.
    Genes Cells, 17: 536-47, 2012.
  23. Moroishi T., Nishiyama M., Takeda Y., Iwai K., Nakayama KI.
    The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
    Cell Metab., 14: 339-51, 2011.
  24. Nishiyama M., Oshikawa K., Tsukada Y., Nakagawa T., Iemura S., Natsume T., Fan Y., Kikuchi A., Skoultchi AI., Nakayama KI.
    CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.
    Nature Cell Biol., 11: 172-82, 2009.
  25. Tsunematsu R., Nishiyama M., Kotoshiba S., Saiga T., Kamura T., Nakayama KI.
    Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.
    Mol. Cell. Biol., 26: 6157-69, 2006.
  26. Fujii Y., Yada M., Nishiyama M., Kamura T., Takahashi H., Tsunematsu R., Susaki E., Nakagawa T., Matsumoto A., Nakayama KI.
    Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation.
    Cancer Sci., 97: 729-36, 2006.
  27. Yada M., Hatakeyama S., Kamura T., Nishiyama M., Tsunematsu R., Imaki H., Ishida N., Okumura F., Nakayama K., Nakayama KI.
    Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
    EMBO J., 23: 2116-25, 2004.
  28. Nishiyama M., Nakayama K., Tsunematsu R., Tsukiyama T., Kikuchi A., Nakayama KI.
    Early embryonic death in mice lacking the beta-catenin-binding protein Duplin.
    Mol. Cell. Biol., 24: 8386-94, 2004.
  29. Tsunematsu R., Nakayama K., Oike Y., Nishiyama M., Ishida N., Hatakeyama S., Bessho Y., Kageyama R., Suda T., Nakayama KI.
    Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
    J. Biol. Chem., 279: 9417-23, 2004.

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